STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
obscnaObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a. (1992 aa)    
Predicted Functional Partners:
obscnb
Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b.
 
   
0.923
ubxn11
UBX domain protein 11.
      
 0.637
neb
Nebulin.
   
 
 0.633
rnf213a
E3 ubiquitin-protein ligase rnf213-alpha; E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity (By similarity). Also involved in neuromuscular regulation.
    
 
 0.570
apool
MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
      
 0.568
tp53rk
TP53-regulating kinase.
      
 0.566
spint1b
Serine peptidase inhibitor, Kunitz type 1 b.
      
 0.561
IQSEC1
SEC7 domain-containing protein.
      
 0.560
popdc2
Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding.
   
  
 0.560
mtus2a
Microtubule-associated tumor suppressor candidate 2a.
   
 
 0.557
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.