STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
srd5a3Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity). (309 aa)    
Predicted Functional Partners:
dolk
Dolichol kinase.
     
 0.990
dhdds
Alkyl transferase; Belongs to the UPP synthase family.
   
  
 0.940
nus1
Dehydrodolichyl diphosphate synthase complex subunit nus1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholestero [...]
   
  
 0.939
hsd17b2
Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.925
hsd17b8
FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like.
     
 0.924
cyp19a1a
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
     
 0.924
cyp11c1
Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.
     
 0.923
hsd17b3
Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.922
dolpp1
Dolichyldiphosphatase 1.
      
 0.918
hsd3b2
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family.
     
 0.914
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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