node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cyp11c1 | cyp19a1a | ENSDARP00000061571 | ENSDARP00000111604 | Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.957 |
cyp11c1 | hsd17b2 | ENSDARP00000061571 | ENSDARP00000066984 | Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.964 |
cyp11c1 | hsd17b3 | ENSDARP00000061571 | ENSDARP00000124637 | Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.984 |
cyp11c1 | hsd17b8 | ENSDARP00000061571 | ENSDARP00000001459 | Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.930 |
cyp11c1 | hsd3b2 | ENSDARP00000061571 | ENSDARP00000025516 | Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.988 |
cyp11c1 | srd5a3 | ENSDARP00000061571 | ENSDARP00000063577 | Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity). | 0.923 |
cyp19a1a | cyp11c1 | ENSDARP00000111604 | ENSDARP00000061571 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. | 0.957 |
cyp19a1a | hsd17b2 | ENSDARP00000111604 | ENSDARP00000066984 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.960 |
cyp19a1a | hsd17b3 | ENSDARP00000111604 | ENSDARP00000124637 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.981 |
cyp19a1a | hsd17b8 | ENSDARP00000111604 | ENSDARP00000001459 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like. | 0.944 |
cyp19a1a | hsd3b2 | ENSDARP00000111604 | ENSDARP00000025516 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. | 0.992 |
cyp19a1a | srd5a3 | ENSDARP00000111604 | ENSDARP00000063577 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity). | 0.924 |
dhdds | dolk | ENSDARP00000058289 | ENSDARP00000099663 | Alkyl transferase; Belongs to the UPP synthase family. | Dolichol kinase. | 0.912 |
dhdds | dolpp1 | ENSDARP00000058289 | ENSDARP00000133381 | Alkyl transferase; Belongs to the UPP synthase family. | Dolichyldiphosphatase 1. | 0.939 |
dhdds | nus1 | ENSDARP00000058289 | ENSDARP00000034808 | Alkyl transferase; Belongs to the UPP synthase family. | Dehydrodolichyl diphosphate synthase complex subunit nus1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholestero [...] | 0.999 |
dhdds | srd5a3 | ENSDARP00000058289 | ENSDARP00000063577 | Alkyl transferase; Belongs to the UPP synthase family. | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity). | 0.940 |
dolk | dhdds | ENSDARP00000099663 | ENSDARP00000058289 | Dolichol kinase. | Alkyl transferase; Belongs to the UPP synthase family. | 0.912 |
dolk | dolpp1 | ENSDARP00000099663 | ENSDARP00000133381 | Dolichol kinase. | Dolichyldiphosphatase 1. | 0.991 |
dolk | nus1 | ENSDARP00000099663 | ENSDARP00000034808 | Dolichol kinase. | Dehydrodolichyl diphosphate synthase complex subunit nus1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholestero [...] | 0.819 |
dolk | srd5a3 | ENSDARP00000099663 | ENSDARP00000063577 | Dolichol kinase. | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity). | 0.990 |