Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
srd5a3Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT) (By similarity). (309 aa)    
Predicted Functional Partners:
srd5a1
3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
     
 0.993
hsd17b2
Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.969
cyp19a1a
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
     
 0.965
hsd17b8
FabG (Beta-ketoacyl-[acyl-carrier-protein] reductase, E. coli) like.
     
 0.958
hsd17b3
Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.958
cyp11c1
Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.
     
 0.955
cyp21a2
Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family.
     
 0.948
ugt5d1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
     
  0.944
dhrsx
Dehydrogenase/reductase (SDR family) X-linked.
     
 0.944
hsd3b2
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family.
     
 0.938
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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