Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
prkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)    
Predicted Functional Partners:
llgl2
LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family.
    
 0.992
pard6a
Par-6 family cell polarity regulator alpha.
    
 0.990
pard6b
Par-6 partitioning defective 6 homolog beta (C. elegans).
    
 0.987
pard3ab
Par-3 family cell polarity regulator alpha, b.
    
 0.982
PARD3
Par-3 family cell polarity regulator.
    
 0.979
pard6gb
Par-6 partitioning defective 6-like protein gamma.
    
 0.961
pard6ga
Par-6 family cell polarity regulator gamma a.
    
 0.961
stk11
Serine/threonine kinase 11; Belongs to the protein kinase superfamily.
    
 0.954
pik3cd
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 0.951
pik3cb
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
   
 0.951
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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