STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sprnShadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. (132 aa)    
Predicted Functional Partners:
prnprs3
Prion protein,-related sequence 3.
      
 0.898
prnpb
Prion protein b.
      
 0.871
spire1a
Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with fmn2, promotes assembly of nuclear actin filaments in [...]
      
 0.727
lingo1b
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
   
    0.499
ptk2aa
Protein tyrosine kinase 2aa.
      
 0.471
appa
Amyloid beta (A4) precursor protein a.
   
  
 0.455
prss59.1
Serine protease 59, tandem duplicate 1; Belongs to the peptidase S1 family.
      
 0.406
raf1b
Raf-1 proto-oncogene, serine/threonine kinase b.
      
 0.400
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.