node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
anapc7 | klhl5 | ENSDARP00000086117 | ENSDARP00000083875 | Anaphase-promoting complex subunit 7. | Kelch-like family member 5. | 0.801 |
anapc7 | siah2l | ENSDARP00000086117 | ENSDARP00000065168 | Anaphase-promoting complex subunit 7. | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | 0.588 |
axin1 | siah2l | ENSDARP00000135613 | ENSDARP00000065168 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | 0.600 |
cacybp | siah2l | ENSDARP00000089504 | ENSDARP00000065168 | Calcyclin-binding protein. | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | 0.804 |
klhl5 | anapc7 | ENSDARP00000083875 | ENSDARP00000086117 | Kelch-like family member 5. | Anaphase-promoting complex subunit 7. | 0.801 |
klhl5 | siah2l | ENSDARP00000083875 | ENSDARP00000065168 | Kelch-like family member 5. | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | 0.711 |
lats2 | siah2l | ENSDARP00000114142 | ENSDARP00000065168 | Large tumor suppressor kinase 2. | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | 0.691 |
plekhf2 | plekhh2 | ENSDARP00000038743 | ENSDARP00000118142 | Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. | Pleckstrin homology domain-containing, family H (with MyTH4 domain) member 2. | 0.898 |
plekhf2 | siah2l | ENSDARP00000038743 | ENSDARP00000065168 | Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | 0.597 |
plekhh2 | plekhf2 | ENSDARP00000118142 | ENSDARP00000038743 | Pleckstrin homology domain-containing, family H (with MyTH4 domain) member 2. | Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. | 0.898 |
plekhh2 | siah2l | ENSDARP00000118142 | ENSDARP00000065168 | Pleckstrin homology domain-containing, family H (with MyTH4 domain) member 2. | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | 0.584 |
siah2l | anapc7 | ENSDARP00000065168 | ENSDARP00000086117 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Anaphase-promoting complex subunit 7. | 0.588 |
siah2l | axin1 | ENSDARP00000065168 | ENSDARP00000135613 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | 0.600 |
siah2l | cacybp | ENSDARP00000065168 | ENSDARP00000089504 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Calcyclin-binding protein. | 0.804 |
siah2l | klhl5 | ENSDARP00000065168 | ENSDARP00000083875 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Kelch-like family member 5. | 0.711 |
siah2l | lats2 | ENSDARP00000065168 | ENSDARP00000114142 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Large tumor suppressor kinase 2. | 0.691 |
siah2l | plekhf2 | ENSDARP00000065168 | ENSDARP00000038743 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. | 0.597 |
siah2l | plekhh2 | ENSDARP00000065168 | ENSDARP00000118142 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Pleckstrin homology domain-containing, family H (with MyTH4 domain) member 2. | 0.584 |
siah2l | sinup | ENSDARP00000065168 | ENSDARP00000019122 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Siaz-interacting nuclear protein. | 0.746 |
siah2l | ube2v2 | ENSDARP00000065168 | ENSDARP00000004795 | E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity). | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] | 0.766 |