STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpn3Gpn-loop gtpase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import (285 aa)    
Predicted Functional Partners:
rpap2
Putative RNA polymerase II subunit B1 CTD phosphatase rpap2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family
   
 
 0.878
polr2c
Polymerase (RNA) II (DNA directed) polypeptide C
   
 
 0.876
GPN1
Gpn-loop gtpase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import
   
 
0.858
polr2l
Dna-directed rna polymerases i, ii, and iii subunit rpabc5; Polymerase (RNA) II (DNA directed) polypeptide L
   
 
 0.853
pih1d1
PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity)
   
 
 0.847
polr2eb
Dna-directed rna polymerases i, ii, and iii subunit rpabc1; Polymerase (RNA) II (DNA directed) polypeptide E, b
   
 
 0.835
polr2ea
Dna-directed rna polymerases i, ii, and iii subunit rpabc1-like; Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
   
 
 0.835
polr2f
Dna-directed rna polymerases i, ii, and iii subunit rpabc2; Polymerase (RNA) II (DNA directed) polypeptide F
   
 
 0.826
polr1d
DNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity)
   
 
 0.804
rpap1
RNA polymerase II associated protein 1
   
  
 0.785
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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