STRINGSTRING
apex1 protein (Danio rerio) - STRING interaction network
"apex1" - DNA-(apurinic or apyrimidinic site) lyase in Danio rerio
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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apex1DNA-(apurinic or apyrimidinic site) lyase; Function as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’-deoxyribose phosphate and 3’-hydroxyl ends. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Required for passage through the midblastula transi [...] (310 aa)    
Predicted Functional Partners:
nthl1
Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family (402 aa)
 
  0.996
mutyh
Si-ch211-241d21.5; mutY homolog (E. coli) (526 aa)
     
  0.987
ENSDARG00000060002
8-oxoguanine DNA glycosylase (391 aa)
   
  0.986
fen1
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a [...] (380 aa)
     
  0.985
polb
DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5’-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5’ sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3’ end of the arising single-nucleotide gap. Conducts ’gap-filling’ DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity) (339 aa)
     
  0.980
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand; Belongs to the PCNA family (260 aa)
   
  0.978
unga
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (291 aa)
   
  0.976
LIG1
Ligase I, DNA, ATP-dependent (1058 aa)
   
 
  0.975
parp1
Poly (ADP-ribose) polymerase family, member 1 (1013 aa)
     
 
  0.972
tdg
Thymine DNA glycosylase, tandem duplicate 1; thymine-DNA glycosylase (441 aa)
   
 
  0.964
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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