STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spty2d1Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-fo [...] (629 aa)    
Predicted Functional Partners:
mrpl40
Mitochondrial ribosomal protein L40.
   
  
 0.815
utp11
U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.
   
 
 0.812
mphosph8
M-phase phosphoprotein 8.
   
 
 0.779
nipa2
Non imprinted in Prader-Willi/Angelman syndrome 2 (Human).
      
 0.750
uevld
Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination. In the N-terminal section; belongs to the ubiquitin- conjugating enzyme family. UEV subfamily.
   
 
 0.744
ech1
Enoyl CoA hydratase 1, peroxisomal.
      
 0.706
arglu1b
Arginine and glutamate-rich protein 1-B; Belongs to the UPF0430 family.
   
 
 0.607
srrm2
Serine/arginine repetitive matrix 2.
   
 
 0.585
tubgcp3
Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.
   
 
 0.577
her4.2
Hairy-related 4, tandem duplicate 2.
      
 0.570
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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