node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ISCU | abcb7 | ENSDARP00000051606 | ENSDARP00000085602 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | 0.870 |
ISCU | fdx2 | ENSDARP00000051606 | ENSDARP00000131094 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.977 |
ISCU | fxn | ENSDARP00000051606 | ENSDARP00000115873 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Frataxin. | 0.998 |
ISCU | glrx5 | ENSDARP00000051606 | ENSDARP00000064111 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Required for normal hemoglobin biosynthesis. | 0.883 |
ISCU | iba57 | ENSDARP00000051606 | ENSDARP00000055617 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Putative transferase CAF17 homolog, mitochondrial; Required for normal heme biosynthesis. | 0.883 |
ISCU | isca1 | ENSDARP00000051606 | ENSDARP00000068166 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Belongs to the HesB/IscA family. | 0.968 |
ISCU | isca2 | ENSDARP00000051606 | ENSDARP00000055610 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Iron-sulfur cluster assembly 2. | 0.965 |
ISCU | lias | ENSDARP00000051606 | ENSDARP00000035286 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.910 |
ISCU | nfs1 | ENSDARP00000051606 | ENSDARP00000084180 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFS1 nitrogen fixation 1 (S. cerevisiae). | 0.999 |
ISCU | nfu1 | ENSDARP00000051606 | ENSDARP00000114381 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae). | 0.959 |
abcb7 | ISCU | ENSDARP00000085602 | ENSDARP00000051606 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.870 |
abcb7 | fdx2 | ENSDARP00000085602 | ENSDARP00000131094 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.744 |
abcb7 | fxn | ENSDARP00000085602 | ENSDARP00000115873 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Frataxin. | 0.948 |
abcb7 | glrx5 | ENSDARP00000085602 | ENSDARP00000064111 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Required for normal hemoglobin biosynthesis. | 0.960 |
abcb7 | iba57 | ENSDARP00000085602 | ENSDARP00000055617 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Putative transferase CAF17 homolog, mitochondrial; Required for normal heme biosynthesis. | 0.890 |
abcb7 | isca1 | ENSDARP00000085602 | ENSDARP00000068166 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Belongs to the HesB/IscA family. | 0.910 |
abcb7 | isca2 | ENSDARP00000085602 | ENSDARP00000055610 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Iron-sulfur cluster assembly 2. | 0.860 |
abcb7 | lias | ENSDARP00000085602 | ENSDARP00000035286 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.814 |
abcb7 | nfs1 | ENSDARP00000085602 | ENSDARP00000084180 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | NFS1 nitrogen fixation 1 (S. cerevisiae). | 0.950 |
abcb7 | nfu1 | ENSDARP00000085602 | ENSDARP00000114381 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae). | 0.817 |