node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYTB | rag1 | ENSDARP00000087881 | ENSDARP00000120100 | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] | 0.852 |
CYTB | rag2 | ENSDARP00000087881 | ENSDARP00000068402 | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] | 0.776 |
CYTB | tmem232 | ENSDARP00000087881 | ENSDARP00000088180 | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. | Transmembrane protein 232. | 0.501 |
cd4-1 | ighz | ENSDARP00000121210 | ENSDARP00000126008 | CD4-1 molecule. | Immunoglobulin heavy constant zeta. | 0.470 |
cd4-1 | lck | ENSDARP00000121210 | ENSDARP00000131919 | CD4-1 molecule. | Tyrosine-protein kinase. | 0.917 |
cd4-1 | rag1 | ENSDARP00000121210 | ENSDARP00000120100 | CD4-1 molecule. | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] | 0.844 |
cd4-1 | rag2 | ENSDARP00000121210 | ENSDARP00000068402 | CD4-1 molecule. | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] | 0.855 |
cd4-1 | runx1 | ENSDARP00000121210 | ENSDARP00000112019 | CD4-1 molecule. | Runt-related transcription factor. | 0.557 |
cd4-1 | tmem232 | ENSDARP00000121210 | ENSDARP00000088180 | CD4-1 molecule. | Transmembrane protein 232. | 0.532 |
fah | prkdc | ENSDARP00000149145 | ENSDARP00000051678 | Fumarylacetoacetase. | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. | 0.492 |
fah | rag1 | ENSDARP00000149145 | ENSDARP00000120100 | Fumarylacetoacetase. | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] | 0.593 |
fah | rag2 | ENSDARP00000149145 | ENSDARP00000068402 | Fumarylacetoacetase. | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] | 0.807 |
ighz | cd4-1 | ENSDARP00000126008 | ENSDARP00000121210 | Immunoglobulin heavy constant zeta. | CD4-1 molecule. | 0.470 |
ighz | lck | ENSDARP00000126008 | ENSDARP00000131919 | Immunoglobulin heavy constant zeta. | Tyrosine-protein kinase. | 0.669 |
ighz | rag1 | ENSDARP00000126008 | ENSDARP00000120100 | Immunoglobulin heavy constant zeta. | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] | 0.744 |
ighz | rag2 | ENSDARP00000126008 | ENSDARP00000068402 | Immunoglobulin heavy constant zeta. | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] | 0.743 |
lck | cd4-1 | ENSDARP00000131919 | ENSDARP00000121210 | Tyrosine-protein kinase. | CD4-1 molecule. | 0.917 |
lck | ighz | ENSDARP00000131919 | ENSDARP00000126008 | Tyrosine-protein kinase. | Immunoglobulin heavy constant zeta. | 0.669 |
lck | myca | ENSDARP00000131919 | ENSDARP00000100455 | Tyrosine-protein kinase. | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. | 0.432 |
lck | prkdc | ENSDARP00000131919 | ENSDARP00000051678 | Tyrosine-protein kinase. | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. | 0.411 |