STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bdh23-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). (245 aa)    
Predicted Functional Partners:
oxct1b
Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
  
 0.932
aacs
Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.930
oxct1a
Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
  
 0.930
hmgcl
3-hydroxy-3-methylglutaryl-CoA lyase.
   
 
 0.930
hmgcll1
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
   
 
 0.930
bdh1
3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
0.913
acaa1
Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.824
hao2
Hydroxyacid oxidase 2 (long chain).
   
 0.625
gpd2
Glycerol-3-phosphate dehydrogenase 2 (mitochondrial).
   
 
 0.624
pgm2
Phosphoglucomutase 2.
   
 0.600
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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