node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aacs | acaa1 | ENSDARP00000002180 | ENSDARP00000017622 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.595 |
aacs | bdh1 | ENSDARP00000002180 | ENSDARP00000119870 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.918 |
aacs | bdh2 | ENSDARP00000002180 | ENSDARP00000069085 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.930 |
aacs | hmgcl | ENSDARP00000002180 | ENSDARP00000026028 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.961 |
aacs | hmgcll1 | ENSDARP00000002180 | ENSDARP00000133158 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.961 |
aacs | oxct1a | ENSDARP00000002180 | ENSDARP00000002234 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.924 |
aacs | oxct1b | ENSDARP00000002180 | ENSDARP00000074184 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.924 |
acaa1 | aacs | ENSDARP00000017622 | ENSDARP00000002180 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.595 |
acaa1 | bdh1 | ENSDARP00000017622 | ENSDARP00000119870 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.490 |
acaa1 | bdh2 | ENSDARP00000017622 | ENSDARP00000069085 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.824 |
acaa1 | hao2 | ENSDARP00000017622 | ENSDARP00000037427 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacid oxidase 2 (long chain). | 0.866 |
acaa1 | hmgcl | ENSDARP00000017622 | ENSDARP00000026028 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.954 |
acaa1 | hmgcll1 | ENSDARP00000017622 | ENSDARP00000133158 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.948 |
acaa1 | oxct1a | ENSDARP00000017622 | ENSDARP00000002234 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.916 |
acaa1 | oxct1b | ENSDARP00000017622 | ENSDARP00000074184 | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.922 |
bdh1 | aacs | ENSDARP00000119870 | ENSDARP00000002180 | 3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.918 |
bdh1 | acaa1 | ENSDARP00000119870 | ENSDARP00000017622 | 3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.490 |
bdh1 | bdh2 | ENSDARP00000119870 | ENSDARP00000069085 | 3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with lcn2 (By similarity). It thereby plays a key role in iron assimilation and homeostasis. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.913 |
bdh1 | hmgcl | ENSDARP00000119870 | ENSDARP00000026028 | 3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.923 |
bdh1 | hmgcll1 | ENSDARP00000119870 | ENSDARP00000133158 | 3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.923 |