STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
slc25a28Mitoferrin-2; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (Probable). (396 aa)    
Predicted Functional Partners:
fxn
Frataxin.
   
 
 0.936
abcb10
ATP-binding cassette, sub-family B (MDR/TAP), member 10.
   
 
 0.918
fech
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
   
  
 0.906
abcb7
ATP-binding cassette, sub-family B (MDR/TAP), member 7.
    
 
 0.861
nfs1
NFS1 nitrogen fixation 1 (S. cerevisiae).
   
  
 0.812
aco1
Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.
    
 
 0.769
nars2
Asparaginyl-tRNA synthetase 2, mitochondrial.
 
      0.769
ISCU
Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
   
  
 0.758
steap3
STEAP family member 3, metalloreductase.
      
 0.742
glrx5
Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Required for normal hemoglobin biosynthesis.
   
  
 0.730
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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