STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kazald3Kazal-type serine peptidase inhibitor domain 3. (296 aa)    
Predicted Functional Partners:
poll
Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.
      
 0.742
npm3
Nucleophosmin/nucleoplasmin, 3.
      
 0.742
wdr11
WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles.
      
 0.729
aup1
Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome; Belongs to the AUP1 family.
      
 0.661
tlx2
T cell leukemia homeobox 2.
      
 0.645
fbxw4
F-box and WD repeat domain-containing 4.
      
 0.645
lbx2
Ladybird homeobox homolog 2 (Drosophila).
      
 0.644
kcnip3b
Kv channel-interacting protein 3b, calsenilin.
      
 0.604
loxl4
Lysyl oxidase-like 4.
   
  
 0.563
lbx1a
Novel protein similar to zebrafish lady bird-like homeobox 1 Drosophila homolog (Lbx1h).
      
 0.562
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.