STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdkn1bbCyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)    
Predicted Functional Partners:
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.980
ccne1
G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily.
   
 0.972
ccna1
Cyclin A1; Belongs to the cyclin family.
    
 0.968
ccne2
Cyclin E2; Belongs to the cyclin family.
   
 0.968
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
    
 0.941
akt1
Non-specific serine/threonine protein kinase.
    
 0.939
akt3a
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.937
ccnd1
G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition.
   
 0.930
akt2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.921
akt3b
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.921
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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