node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cacna1da | sobpa | ENSDARP00000137557 | ENSDARP00000070897 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | 0.513 |
camk4 | ccdc40 | ENSDARP00000108452 | ENSDARP00000139124 | Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. | 0.445 |
camk4 | sobpa | ENSDARP00000108452 | ENSDARP00000070897 | Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | 0.648 |
camk4 | ssbp3a | ENSDARP00000108452 | ENSDARP00000075515 | Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. | Single stranded DNA-binding protein 3a. | 0.400 |
ccdc40 | camk4 | ENSDARP00000139124 | ENSDARP00000108452 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. | Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. | 0.445 |
ccdc40 | ripply1 | ENSDARP00000139124 | ENSDARP00000154427 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. | 0.643 |
ccdc40 | sobpa | ENSDARP00000139124 | ENSDARP00000070897 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | 0.646 |
ephb3a | sobpa | ENSDARP00000040208 | ENSDARP00000070897 | Ephrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance plays also an important re [...] | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | 0.553 |
nr2e1 | sobpa | ENSDARP00000013317 | ENSDARP00000070897 | Nuclear receptor subfamily 2, group E, member 1. | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | 0.540 |
ripply1 | ccdc40 | ENSDARP00000154427 | ENSDARP00000139124 | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. | 0.643 |
ripply1 | sobpa | ENSDARP00000154427 | ENSDARP00000070897 | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | 0.664 |
sec63 | sobpa | ENSDARP00000006629 | ENSDARP00000070897 | SEC63 homolog, protein translocation regulator. | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | 0.693 |
sobpa | cacna1da | ENSDARP00000070897 | ENSDARP00000137557 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.513 |
sobpa | camk4 | ENSDARP00000070897 | ENSDARP00000108452 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. | 0.648 |
sobpa | ccdc40 | ENSDARP00000070897 | ENSDARP00000139124 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. | 0.646 |
sobpa | ephb3a | ENSDARP00000070897 | ENSDARP00000040208 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | Ephrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance plays also an important re [...] | 0.553 |
sobpa | nr2e1 | ENSDARP00000070897 | ENSDARP00000013317 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | Nuclear receptor subfamily 2, group E, member 1. | 0.540 |
sobpa | ripply1 | ENSDARP00000070897 | ENSDARP00000154427 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites. | 0.664 |
sobpa | sec63 | ENSDARP00000070897 | ENSDARP00000006629 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | SEC63 homolog, protein translocation regulator. | 0.693 |
sobpa | ssbp3a | ENSDARP00000070897 | ENSDARP00000075515 | Sine oculis-binding protein homolog A; Implicated in development of the cochlea. | Single stranded DNA-binding protein 3a. | 0.803 |