node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
and1 | hhex | ENSDARP00000144256 | ENSDARP00000137249 | Actinodin1. | Hematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. | 0.453 |
and1 | prox1a | ENSDARP00000144256 | ENSDARP00000071943 | Actinodin1. | Prospero homeobox 1a. | 0.744 |
ccbe1 | fli1a | ENSDARP00000106577 | ENSDARP00000071331 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Fli-1 proto-oncogene, ETS transcription factor a. | 0.569 |
ccbe1 | flt4 | ENSDARP00000106577 | ENSDARP00000133227 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.868 |
ccbe1 | lyve1a | ENSDARP00000106577 | ENSDARP00000104347 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Lymphatic vessel endothelial hyaluronic receptor 1a. | 0.488 |
ccbe1 | lyve1b | ENSDARP00000106577 | ENSDARP00000155383 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.833 |
ccbe1 | nr2f2 | ENSDARP00000106577 | ENSDARP00000107285 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Drosophila seven-up homolog/mammalian ARP-1 homolog. | 0.589 |
ccbe1 | prox1a | ENSDARP00000106577 | ENSDARP00000071943 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Prospero homeobox 1a. | 0.745 |
ccbe1 | sox18 | ENSDARP00000106577 | ENSDARP00000113837 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | SRY-box transcription factor 18. | 0.837 |
ccbe1 | vegfc | ENSDARP00000106577 | ENSDARP00000092263 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.960 |
fli1a | ccbe1 | ENSDARP00000071331 | ENSDARP00000106577 | Fli-1 proto-oncogene, ETS transcription factor a. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | 0.569 |
fli1a | flt4 | ENSDARP00000071331 | ENSDARP00000133227 | Fli-1 proto-oncogene, ETS transcription factor a. | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | 0.845 |
fli1a | lyve1b | ENSDARP00000071331 | ENSDARP00000155383 | Fli-1 proto-oncogene, ETS transcription factor a. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.693 |
fli1a | prox1a | ENSDARP00000071331 | ENSDARP00000071943 | Fli-1 proto-oncogene, ETS transcription factor a. | Prospero homeobox 1a. | 0.701 |
fli1a | sox18 | ENSDARP00000071331 | ENSDARP00000113837 | Fli-1 proto-oncogene, ETS transcription factor a. | SRY-box transcription factor 18. | 0.447 |
fli1a | vegfc | ENSDARP00000071331 | ENSDARP00000092263 | Fli-1 proto-oncogene, ETS transcription factor a. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.675 |
flt4 | ccbe1 | ENSDARP00000133227 | ENSDARP00000106577 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. | 0.868 |
flt4 | fli1a | ENSDARP00000133227 | ENSDARP00000071331 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Fli-1 proto-oncogene, ETS transcription factor a. | 0.845 |
flt4 | lyve1a | ENSDARP00000133227 | ENSDARP00000104347 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Lymphatic vessel endothelial hyaluronic receptor 1a. | 0.753 |
flt4 | lyve1b | ENSDARP00000133227 | ENSDARP00000155383 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. | Lymphatic vessel endothelial hyaluronic receptor 1b. | 0.954 |