STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F1QQY3_DANRESortilin. (423 aa)    
Predicted Functional Partners:
nts
Neurotensin.
    
 
 0.939
sort1b
Sortilin.
  
  
0.905
sort1a
Sortilin; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Belongs to the VPS10-related sortilin family. SORT1 subfamily.
  
  
0.905
bdnf
Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.
    
 
 0.848
gga1
Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1.
    
 
 0.839
grnb
Granulin b.
    
 
 0.789
psap
Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
    
 
 0.774
ngfra
Nerve growth factor receptor a (TNFR superfamily, member 16).
    
 
 0.756
ngfa
Neurotrophin-7; Recombinant ZNT-7 was able to bind to the human p75 neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC, indicating a similar receptor specificity as NGF; Belongs to the NGF-beta family.
    
 
 0.751
tmem106bb
Transmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking; Belongs to the TMEM106 family.
      
 0.748
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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