STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sp8bTranscription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Belongs to the Sp1 C2H2-type zinc-finger protein family. (455 aa)    
Predicted Functional Partners:
rh50
Rh50-like protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
   
  
 0.745
lrit3b
Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.
    
 
 0.662
fgfr1op
Chemokine (C-C motif) receptor 6a.
      
 0.648
MEP1B
Meprin A subunit.
      
 0.648
mep1b
Meprin A subunit.
      
 0.648
fgfr1op2
FGFR1 oncogene partner 2 homolog.
   
 
 0.604
rpl23
60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.
    
 
 0.569
nr5a5
Nuclear receptor subfamily 5, group A, member 5.
    
 
 0.549
frs2b
Fibroblast growth factor receptor substrate 2b.
   
  
 0.545
trim35-27
Tripartite motif-containing 35-27.
   
 
 0.495
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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