node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ascl1a | dla | ENSDARP00000056004 | ENSDARP00000013374 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | 0.721 |
ascl1a | dlc | ENSDARP00000056004 | ENSDARP00000018643 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | 0.437 |
ascl1a | dld | ENSDARP00000056004 | ENSDARP00000089996 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | 0.530 |
ascl1a | elavl3 | ENSDARP00000056004 | ENSDARP00000030680 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | ELAV-like protein; Belongs to the RRM elav family. | 0.736 |
ascl1a | fabp7a | ENSDARP00000056004 | ENSDARP00000018865 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | Fatty acid-binding protein 7, brain, a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.498 |
ascl1a | her4.1 | ENSDARP00000056004 | ENSDARP00000073730 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | Hairy-related 4, tandem duplicate 1. | 0.806 |
ascl1a | insm1a | ENSDARP00000056004 | ENSDARP00000107863 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | Insulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). | 0.898 |
ascl1a | notch1a | ENSDARP00000056004 | ENSDARP00000137942 | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.788 |
dla | ascl1a | ENSDARP00000013374 | ENSDARP00000056004 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | 0.721 |
dla | elavl3 | ENSDARP00000013374 | ENSDARP00000030680 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | ELAV-like protein; Belongs to the RRM elav family. | 0.614 |
dla | her4.1 | ENSDARP00000013374 | ENSDARP00000073730 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Hairy-related 4, tandem duplicate 1. | 0.833 |
dla | insm1a | ENSDARP00000013374 | ENSDARP00000107863 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Insulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). | 0.460 |
dla | notch1a | ENSDARP00000013374 | ENSDARP00000137942 | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.863 |
dlc | ascl1a | ENSDARP00000018643 | ENSDARP00000056004 | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | 0.437 |
dlc | dld | ENSDARP00000018643 | ENSDARP00000089996 | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | 0.476 |
dlc | her4.1 | ENSDARP00000018643 | ENSDARP00000073730 | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | Hairy-related 4, tandem duplicate 1. | 0.691 |
dlc | notch1a | ENSDARP00000018643 | ENSDARP00000137942 | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.858 |
dld | ascl1a | ENSDARP00000089996 | ENSDARP00000056004 | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. | 0.530 |
dld | dlc | ENSDARP00000089996 | ENSDARP00000018643 | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | 0.476 |
dld | her4.1 | ENSDARP00000089996 | ENSDARP00000073730 | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. | Hairy-related 4, tandem duplicate 1. | 0.743 |