Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LOC103910107 | caspa | ENSDARP00000133511 | ENSDARP00000034228 | NACHT domain-containing protein. | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | 0.904 |
| LOC103910107 | caspbl | ENSDARP00000133511 | ENSDARP00000113551 | NACHT domain-containing protein. | Caspase b,-like; Belongs to the peptidase C14A family. | 0.904 |
| LOC103910107 | nek7 | ENSDARP00000133511 | ENSDARP00000073991 | NACHT domain-containing protein. | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | 0.906 |
| anks3 | invs | ENSDARP00000123123 | ENSDARP00000014904 | Ankyrin repeat and sterile alpha motif domain-containing 3. | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. | 0.417 |
| anks3 | nek7 | ENSDARP00000123123 | ENSDARP00000073991 | Ankyrin repeat and sterile alpha motif domain-containing 3. | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | 0.957 |
| anks3 | nphp1 | ENSDARP00000123123 | ENSDARP00000063715 | Ankyrin repeat and sterile alpha motif domain-containing 3. | Nephronophthisis 1. | 0.860 |
| caspa | LOC103910107 | ENSDARP00000034228 | ENSDARP00000133511 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | NACHT domain-containing protein. | 0.904 |
| caspa | caspbl | ENSDARP00000034228 | ENSDARP00000113551 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Caspase b,-like; Belongs to the peptidase C14A family. | 0.908 |
| caspa | nek7 | ENSDARP00000034228 | ENSDARP00000073991 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | 0.697 |
| caspbl | LOC103910107 | ENSDARP00000113551 | ENSDARP00000133511 | Caspase b,-like; Belongs to the peptidase C14A family. | NACHT domain-containing protein. | 0.904 |
| caspbl | caspa | ENSDARP00000113551 | ENSDARP00000034228 | Caspase b,-like; Belongs to the peptidase C14A family. | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | 0.908 |
| caspbl | nek7 | ENSDARP00000113551 | ENSDARP00000073991 | Caspase b,-like; Belongs to the peptidase C14A family. | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | 0.684 |
| fcf1 | nek7 | ENSDARP00000130801 | ENSDARP00000073991 | FCF1 rRNA-processing protein. | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | 0.540 |
| fcf1 | unc45a | ENSDARP00000130801 | ENSDARP00000137669 | FCF1 rRNA-processing protein. | Unc-45 myosin chaperone A. | 0.570 |
| invs | anks3 | ENSDARP00000014904 | ENSDARP00000123123 | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. | Ankyrin repeat and sterile alpha motif domain-containing 3. | 0.417 |
| invs | nek7 | ENSDARP00000014904 | ENSDARP00000073991 | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | 0.594 |
| invs | nphp1 | ENSDARP00000014904 | ENSDARP00000063715 | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. | Nephronophthisis 1. | 0.936 |
| mtif2 | nek7 | ENSDARP00000086605 | ENSDARP00000073991 | Mitochondrial translational initiation factor 2. | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | 0.749 |
| nek7 | LOC103910107 | ENSDARP00000073991 | ENSDARP00000133511 | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | NACHT domain-containing protein. | 0.906 |
| nek7 | anks3 | ENSDARP00000073991 | ENSDARP00000123123 | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. | Ankyrin repeat and sterile alpha motif domain-containing 3. | 0.957 |
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