STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tpteTransmembrane phosphatase with tensin homology. (511 aa)    
Predicted Functional Partners:
hvcn1
Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity).
      
 0.848
ano2b
Anoctamin.
   
  
 0.808
sprtn
SprT-like N-terminal domain.
   
    0.799
kcnq3
Potassium voltage-gated channel, KQT-like subfamily, member 3; Belongs to the potassium channel family.
    
 
 0.769
trpc3
Transient receptor potential cation channel, subfamily C, member 3; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.744
LOC100537815
Potassium voltage-gated channel, shaker-related subfamily, member 2a; Belongs to the potassium channel family.
    
 
 0.731
plek
Pleckstrin.
   
  
 0.706
plek2
Plek2 protein.
      
 0.702
calm2a
Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
    
 
 0.679
trpc4b
Transient receptor potential cation channel, subfamily C, member 4b; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.667
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]