node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cdc6 | cdca8 | ENSDARP00000008736 | ENSDARP00000143774 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | 0.703 |
cdc6 | dlgap5 | ENSDARP00000008736 | ENSDARP00000066410 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Discs, large (Drosophila) homolog-associated protein 5. | 0.883 |
cdc6 | e2f4 | ENSDARP00000008736 | ENSDARP00000132304 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | E2F transcription factor 4. | 0.540 |
cdc6 | e2f7 | ENSDARP00000008736 | ENSDARP00000117568 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of spro [...] | 0.661 |
cdc6 | e2f8 | ENSDARP00000008736 | ENSDARP00000105923 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of spro [...] | 0.590 |
cdc6 | foxm1 | ENSDARP00000008736 | ENSDARP00000009248 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Forkhead box M1. | 0.445 |
cdc6 | kif11 | ENSDARP00000008736 | ENSDARP00000006884 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.866 |
cdc6 | rbl2 | ENSDARP00000008736 | ENSDARP00000067923 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Retinoblastoma-like 2 (p130). | 0.601 |
cdc6 | rrm2 | ENSDARP00000008736 | ENSDARP00000103553 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Ribonucleotide reductase M2 polypeptide. | 0.788 |
cdc6 | tfdp1b | ENSDARP00000008736 | ENSDARP00000022294 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Transcription factor. | 0.473 |
cdca8 | cdc6 | ENSDARP00000143774 | ENSDARP00000008736 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.703 |
cdca8 | dlgap5 | ENSDARP00000143774 | ENSDARP00000066410 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | Discs, large (Drosophila) homolog-associated protein 5. | 0.956 |
cdca8 | e2f7 | ENSDARP00000143774 | ENSDARP00000117568 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of spro [...] | 0.500 |
cdca8 | e2f8 | ENSDARP00000143774 | ENSDARP00000105923 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of spro [...] | 0.648 |
cdca8 | foxm1 | ENSDARP00000143774 | ENSDARP00000009248 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | Forkhead box M1. | 0.882 |
cdca8 | kif11 | ENSDARP00000143774 | ENSDARP00000006884 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.940 |
cdca8 | rrm2 | ENSDARP00000143774 | ENSDARP00000103553 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | Ribonucleotide reductase M2 polypeptide. | 0.756 |
dlgap5 | cdc6 | ENSDARP00000066410 | ENSDARP00000008736 | Discs, large (Drosophila) homolog-associated protein 5. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.883 |
dlgap5 | cdca8 | ENSDARP00000066410 | ENSDARP00000143774 | Discs, large (Drosophila) homolog-associated protein 5. | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). | 0.956 |
dlgap5 | e2f7 | ENSDARP00000066410 | ENSDARP00000117568 | Discs, large (Drosophila) homolog-associated protein 5. | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of spro [...] | 0.601 |