STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
n4bp1NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase itch (849 aa)    
Predicted Functional Partners:
gata3
Transcription factor GATA-3; GATA-binding protein 3
      
 0.839
ada
Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family
      
 0.824
zfand5b
Zinc finger, AN1-type domain 5b
   
  
 0.706
nedd8
Neural precursor cell expressed, developmentally down-regulated 8
   
 
 0.700
rnf19b
E3 ubiquitin-protein ligase RNF19B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death
   
  
 0.694
spsb1
splA/ryanodine receptor domain and SOCS box containing 1
      
 0.683
rab11fip1b
RAB11 family interacting protein 1 (class I) b
      
 0.668
rab11fip1a
RAB11 family interacting protein 1 (class I) a
      
 0.668
NEDD4
E3 ubiquitin-protein ligase; Neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
   
 
 0.642
ecsit
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa- B
      
 0.639
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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