STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
n4bp1NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase itch. Belongs to the N4BP1 family. (858 aa)    
Predicted Functional Partners:
ikbkg
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
   
  0.911
casp8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 
 0.782
nedd8
NEDD8 ubiquitin-like modifier.
    
 
 0.581
nedd8l
NEDD8 ubiquitin-like modifier, like.
    
 
 0.581
usp36
Ubiquitin-specific peptidase 36; Belongs to the peptidase C19 family.
      
 0.561
gramd4a
GRAM domain-containing 4a.
      
 0.477
litaf
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
   
 
 0.475
trim25
Tripartite motif-containing 25.
   
  
 0.462
gig2l
Grass carp reovirus (GCRV)-induced gene 2l.
      
 0.453
sec62
SEC62 homolog, preprotein translocation factor.
      
 0.418
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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