STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
slc17a8Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells; Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. (590 aa)    
Predicted Functional Partners:
otofa
Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses.
      
 0.852
otofb
Otoferlin b.
      
 0.849
slc26a5
Solute carrier family 26, member 5.
      
 0.767
cacna1da
Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
      
 0.743
myo6b
Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
      
 0.703
TMC1
Transmembrane channel-like protein 1; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery ; Belongs to the TMC family.
   
  
 0.662
rims2a
Regulating synaptic membrane exocytosis 2a.
   
  
 0.658
E7FF92_DANRE
C2 domain-containing protein.
   
  
 0.656
RIMS2
Regulating synaptic membrane exocytosis 2.
   
  
 0.655
atoh1a
Atonal bHLH transcription factor 1a.
      
 0.654
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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