STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hspa14Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. (504 aa)    
Predicted Functional Partners:
dnajc2
DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription ac [...]
   
 0.872
dnajb6a
DnaJ heat shock protein family (Hsp40) member B6a.
 
 0.826
dnajb1a
DnaJ heat shock protein family (Hsp40) member B1a.
 
 0.824
dnaja2a
DnaJ heat shock protein family (Hsp40) member A2a.
 
 0.761
dnaja2b
DnaJ heat shock protein family (Hsp40) member A2b.
 
 0.752
dnaja1
DnaJ heat shock protein family (Hsp40) member A1.
 
 0.750
hsbp1a
Heat shock factor-binding protein 1a.
    
 
 0.750
hspa4a
Heat shock protein 4, like.
  
0.749
bag3
BCL2-associated athanogene 3.
   
 0.747
dnajb9a
DnaJ heat shock protein family (Hsp40) member B9a.
 
 0.746
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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