| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ccdc47 | ncln | ENSDARP00000051541 | ENSDARP00000076240 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.940 |
| ccdc47 | rpl19 | ENSDARP00000051541 | ENSDARP00000105649 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | 60S ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.765 |
| ccdc47 | rpl4 | ENSDARP00000051541 | ENSDARP00000060362 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Ribosomal protein L4. | 0.774 |
| ccdc47 | tmco1 | ENSDARP00000051541 | ENSDARP00000091049 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.984 |
| ccdc47 | tmem147 | ENSDARP00000051541 | ENSDARP00000058382 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Transmembrane protein 147. | 0.929 |
| dennd3a | ncln | ENSDARP00000100292 | ENSDARP00000076240 | DENN/MADD domain-containing 3a. | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.812 |
| dennd3a | tbata | ENSDARP00000100292 | ENSDARP00000156994 | DENN/MADD domain-containing 3a. | Thymus, brain and testes-associated. | 0.832 |
| dennd3b | ncln | ENSDARP00000118482 | ENSDARP00000076240 | DENN/MADD domain-containing 3b. | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.782 |
| dennd3b | tbata | ENSDARP00000118482 | ENSDARP00000156994 | DENN/MADD domain-containing 3b. | Thymus, brain and testes-associated. | 0.832 |
| ncln | ccdc47 | ENSDARP00000076240 | ENSDARP00000051541 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | 0.940 |
| ncln | dennd3a | ENSDARP00000076240 | ENSDARP00000100292 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | DENN/MADD domain-containing 3a. | 0.812 |
| ncln | dennd3b | ENSDARP00000076240 | ENSDARP00000118482 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | DENN/MADD domain-containing 3b. | 0.782 |
| ncln | nomo | ENSDARP00000076240 | ENSDARP00000128647 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Nodal modulator. | 0.955 |
| ncln | rpl19 | ENSDARP00000076240 | ENSDARP00000105649 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 60S ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.797 |
| ncln | rpl4 | ENSDARP00000076240 | ENSDARP00000060362 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Ribosomal protein L4. | 0.795 |
| ncln | snrnp35 | ENSDARP00000076240 | ENSDARP00000135151 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | U11/U12 small nuclear ribonucleoprotein 35 kDa protein. | 0.803 |
| ncln | tbata | ENSDARP00000076240 | ENSDARP00000156994 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Thymus, brain and testes-associated. | 0.951 |
| ncln | tmco1 | ENSDARP00000076240 | ENSDARP00000091049 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.909 |
| ncln | tmem147 | ENSDARP00000076240 | ENSDARP00000058382 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Transmembrane protein 147. | 0.985 |
| nomo | ncln | ENSDARP00000128647 | ENSDARP00000076240 | Nodal modulator. | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.955 |