STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thap1THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity); Belongs to the THAP1 family. (225 aa)    
Predicted Functional Partners:
gnal
Guanine nucleotide-binding protein G(olf) subunit alpha.
      
 0.907
col6a3
Collagen, type VI, alpha 3.
      
 0.742
LOC108191316
Collagen, type VI, alpha 3.
      
 0.741
prkar2aa
Protein kinase, cAMP-dependent, regulatory, type II, alpha A.
   
 
 0.512
prkar2ab
Protein kinase, cAMP-dependent, regulatory, type II, alpha, B.
   
 
 0.510
prkar1aa
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) a.
   
 
 0.510
prkar1ab
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b.
   
 
 0.510
prkar1b
Protein kinase, cAMP-dependent, regulatory, type I, beta.
   
 
 0.510
PRKAR2B
Si:ch211-272n13.7.
   
 
 0.510
oat
Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
    
 
 0.501
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.