STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tgif1TGFB-induced factor homeobox 1. (273 aa)    
Predicted Functional Partners:
smad2
Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis.
    
 0.969
smad3a
Mothers against decapentaplegic homolog.
    
 0.933
smad3b
Mothers against decapentaplegic homolog.
   
 0.922
LOC100535338
Homeobox domain-containing protein.
  
  
 
0.905
zic2b
ZIC family member 2 (Odd-paired homolog, Drosophila) B.
   
 
 0.823
six3b
Sine oculis homeobox homolog 3b.
   
  
 0.819
zic2a
ZIC family member 2 (Odd-paired homolog, Drosophila), A.
   
 
 0.812
six3a
Sine oculis homeobox homolog 3a.
      
 0.753
hdac1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 0.688
smad4a
Mothers against decapentaplegic homolog.
   
 0.647
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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