STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sik1Salt-inducible kinase 1. (811 aa)    
Predicted Functional Partners:
adamts15a
ADAM metallopeptidase with thrombospondin type 1 motif, 15a.
   
  
 0.648
cradd
CASP2 and RIPK1 domain-containing adaptor with death domain.
   
  
 0.570
agpat2
1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
      
 0.559
nhsl2
NHS-like 2.
      
 0.540
hsf2bp
Heat shock transcription factor 2-binding protein.
 
    
 0.533
rbm47
RNA-binding motif protein 47.
      
 0.508
crtc2
CREB-regulated transcription coactivator 2.
    
 
 0.486
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b.
      
 0.479
egr1
Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...]
   
 
 0.462
prss59.1
Serine protease 59, tandem duplicate 1; Belongs to the peptidase S1 family.
    
 
 0.446
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.