| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ctnnb1 | ctnnb2 | ENSDARP00000139205 | ENSDARP00000076115 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Catenin, beta 2. | 0.924 |
| ctnnb1 | irs1 | ENSDARP00000139205 | ENSDARP00000070706 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Insulin receptor substrate 1. | 0.411 |
| ctnnb1 | ptprfb | ENSDARP00000139205 | ENSDARP00000077749 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.929 |
| ctnnb2 | ctnnb1 | ENSDARP00000076115 | ENSDARP00000139205 | Catenin, beta 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.924 |
| ctnnb2 | ptprfb | ENSDARP00000076115 | ENSDARP00000077749 | Catenin, beta 2. | Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.919 |
| insra | insrb | ENSDARP00000023951 | ENSDARP00000096601 | Tyrosine-protein kinase receptor. | Tyrosine-protein kinase receptor. | 0.915 |
| insra | irs1 | ENSDARP00000023951 | ENSDARP00000070706 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 1. | 0.969 |
| insra | irs2a | ENSDARP00000023951 | ENSDARP00000053923 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 2a. | 0.976 |
| insra | irs2b | ENSDARP00000023951 | ENSDARP00000136042 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 2b. | 0.974 |
| insra | irs4a | ENSDARP00000023951 | ENSDARP00000110181 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 4a. | 0.965 |
| insra | ptprfb | ENSDARP00000023951 | ENSDARP00000077749 | Tyrosine-protein kinase receptor. | Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.910 |
| insrb | insra | ENSDARP00000096601 | ENSDARP00000023951 | Tyrosine-protein kinase receptor. | Tyrosine-protein kinase receptor. | 0.915 |
| insrb | irs1 | ENSDARP00000096601 | ENSDARP00000070706 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 1. | 0.966 |
| insrb | irs2a | ENSDARP00000096601 | ENSDARP00000053923 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 2a. | 0.968 |
| insrb | irs2b | ENSDARP00000096601 | ENSDARP00000136042 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 2b. | 0.968 |
| insrb | irs4a | ENSDARP00000096601 | ENSDARP00000110181 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 4a. | 0.964 |
| insrb | ptprfb | ENSDARP00000096601 | ENSDARP00000077749 | Tyrosine-protein kinase receptor. | Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.908 |
| irs1 | ctnnb1 | ENSDARP00000070706 | ENSDARP00000139205 | Insulin receptor substrate 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.411 |
| irs1 | insra | ENSDARP00000070706 | ENSDARP00000023951 | Insulin receptor substrate 1. | Tyrosine-protein kinase receptor. | 0.969 |
| irs1 | insrb | ENSDARP00000070706 | ENSDARP00000096601 | Insulin receptor substrate 1. | Tyrosine-protein kinase receptor. | 0.966 |