node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pld4 | pld2 | ENSDARP00000145734 | ENSDARP00000122561 | Uncharacterized protein. | Phospholipase. | 0.779 |
Pld4 | pld6 | ENSDARP00000145734 | ENSDARP00000078381 | Uncharacterized protein. | Mitochondrial cardiolipin hydrolase; Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleavin [...] | 0.898 |
asz1 | fkbp6 | ENSDARP00000021759 | ENSDARP00000047357 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | Peptidylprolyl isomerase. | 0.910 |
asz1 | henmt1 | ENSDARP00000021759 | ENSDARP00000004251 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation. Stabilization of piRNAs is essential for oocyte development. | 0.852 |
asz1 | pld6 | ENSDARP00000021759 | ENSDARP00000078381 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | Mitochondrial cardiolipin hydrolase; Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleavin [...] | 0.968 |
asz1 | tdrd1 | ENSDARP00000021759 | ENSDARP00000127267 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of corr [...] | 0.892 |
asz1 | tdrd12 | ENSDARP00000021759 | ENSDARP00000156644 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | Tudor domain-containing 12. | 0.690 |
asz1 | tdrd5 | ENSDARP00000021759 | ENSDARP00000122775 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). | 0.792 |
asz1 | tdrd9 | ENSDARP00000021759 | ENSDARP00000011360 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | ATP-dependent RNA helicase TDRD9; ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a n [...] | 0.910 |
asz1 | tdrkh | ENSDARP00000021759 | ENSDARP00000005097 | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | Tudor and KH domain-containing. | 0.866 |
fkbp6 | asz1 | ENSDARP00000047357 | ENSDARP00000021759 | Peptidylprolyl isomerase. | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | 0.910 |
fkbp6 | henmt1 | ENSDARP00000047357 | ENSDARP00000004251 | Peptidylprolyl isomerase. | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation. Stabilization of piRNAs is essential for oocyte development. | 0.841 |
fkbp6 | pld6 | ENSDARP00000047357 | ENSDARP00000078381 | Peptidylprolyl isomerase. | Mitochondrial cardiolipin hydrolase; Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleavin [...] | 0.879 |
fkbp6 | tdrd1 | ENSDARP00000047357 | ENSDARP00000127267 | Peptidylprolyl isomerase. | Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of corr [...] | 0.867 |
fkbp6 | tdrd12 | ENSDARP00000047357 | ENSDARP00000156644 | Peptidylprolyl isomerase. | Tudor domain-containing 12. | 0.826 |
fkbp6 | tdrd5 | ENSDARP00000047357 | ENSDARP00000122775 | Peptidylprolyl isomerase. | Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). | 0.855 |
fkbp6 | tdrd9 | ENSDARP00000047357 | ENSDARP00000011360 | Peptidylprolyl isomerase. | ATP-dependent RNA helicase TDRD9; ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a n [...] | 0.879 |
fkbp6 | tdrkh | ENSDARP00000047357 | ENSDARP00000005097 | Peptidylprolyl isomerase. | Tudor and KH domain-containing. | 0.885 |
henmt1 | asz1 | ENSDARP00000004251 | ENSDARP00000021759 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation. Stabilization of piRNAs is essential for oocyte development. | Ankyrin repeat, SAM and basic leucine zipper domain-containing 1. | 0.852 |
henmt1 | fkbp6 | ENSDARP00000004251 | ENSDARP00000047357 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation. Stabilization of piRNAs is essential for oocyte development. | Peptidylprolyl isomerase. | 0.841 |