STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
d2hgdhD-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha- ketoglutarate; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (533 aa)    
Predicted Functional Partners:
l2hgdh
L-2-hydroxyglutarate dehydrogenase.
      
 0.971
trrap
Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.
   
 
 0.873
dmap1
DNA methyltransferase 1-associated protein 1.
   
 
 0.868
meaf6
Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...]
    
 
 0.866
morf4l1
Mortality factor 4-like 1.
   
 
 0.853
yeats4
YEATS domain-containing 4.
   
 
 0.845
idh2
Isocitrate dehydrogenase (NADP(+)) 2.
      
 0.810
tra2b
Transformer 2 beta homolog.
   
 
 0.758
slitrk3a
SLIT and NTRK-like family, member 3a.
      
 0.756
slc25a1a
Tricarboxylate transport protein A, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate (By similarity). Required for proper neuromuscular junction formation.
   
 
 0.722
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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