STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plekha7aPleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. (1264 aa)    
Predicted Functional Partners:
tspan33b
Tetraspanin.
   
  
 0.876
zgc:113223
Tetraspanin.
      
 0.875
tspan33a
Tetraspanin-33.
      
 0.807
mfrp
Membrane frizzled-related protein.
      
 0.663
pcmtd1
Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain-containing 1.
      
 0.647
mysm1
Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
      
 0.595
plekha8
Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN) to the plasma membrane.
      
 0.581
pdzd11
PDZ domain-containing protein 11.
      
 0.567
plekha5
Pleckstrin homology domain-containing, family A member 5.
     
0.552
plekha3
Pleckstrin homology domain-containing, family A (phosphoinositide-binding-specific) member 3.
      
 0.551
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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