Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
march4lE3 ubiquitin-protein ligase MARCHF4; E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (421 aa)    
Predicted Functional Partners:
ogfod1
2-oxoglutarate and iron-dependent oxygenase domain-containing 1.
      
 0.590
ube2ql1
Ubiquitin-conjugating enzyme E2Q family-like 1.
      
 0.587
herpud2
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway.
      
 0.577
zp2.5
Zona pellucida glycoprotein 2, tandem duplicate 5.
      
 0.560
ube2h
Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.533
tmco3
Transmembrane and coiled-coil domains 3.
      
 0.515
march5
E3 ubiquitin-protein ligase MARCH5.
   
  
 0.468
KIRREL3
Kirre like nephrin family adhesion molecule 3.
      
 0.468
march5l
E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.
   
  
 0.452
tmem117
Transmembrane protein 117; May be involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family.
      
 0.446
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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