STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
march4lE3 ubiquitin-protein ligase MARCHF4; E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (421 aa)    
Predicted Functional Partners:
zp2.5
Zona pellucida glycoprotein 2, tandem duplicate 5.
      
 0.662
ogfod1
2-oxoglutarate and iron-dependent oxygenase domain-containing 1.
      
 0.649
ube2ql1
Ubiquitin-conjugating enzyme E2Q family-like 1.
      
 0.638
herpud2
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway.
      
 0.624
cnot2
CCR4-NOT transcription complex, subunit 2.
    
 
 0.584
KIRREL3
Kirre like nephrin family adhesion molecule 3.
      
 0.540
rtn4r
Reticulon 4 receptor.
      
 0.529
ube2g2
Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.447
faf2
Fas-associated factor family member 2.
    
 
 0.433
faf1
Fas (TNFRSF6)-associated factor 1.
    
 
 0.433
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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