trim109 protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

trim109

Tripartite motif-containing 109. (497 aa)

Predicted Functional Partners:

trim33l

0.732

adarb1b

0.732

trim110

0.732

ccl35.1

0.732

trim107

0.732

trim45

0.713

mov10a

0.680

mov10b.2

0.674

ccr6b

0.672

cdc40

0.669

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
adarb1b	ccl35.1	ENSDARP00000113492	ENSDARP00000132604	Adenosine deaminase RNA-specific B1b.	Chemokine (C-C motif) ligand 35, duplicate 1.	0.732
adarb1b	ccr6b	ENSDARP00000113492	ENSDARP00000128924	Adenosine deaminase RNA-specific B1b.	Chemokine (C-C motif) receptor 6b.	0.676
adarb1b	cdc40	ENSDARP00000113492	ENSDARP00000060431	Adenosine deaminase RNA-specific B1b.	Cell division cycle 40 homolog (S. cerevisiae).	0.676
adarb1b	mov10a	ENSDARP00000113492	ENSDARP00000064825	Adenosine deaminase RNA-specific B1b.	Mov10 RISC complex RNA helicase a.	0.690
adarb1b	mov10b.2	ENSDARP00000113492	ENSDARP00000072953	Adenosine deaminase RNA-specific B1b.	Putative helicase mov-10-B.2; Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).	0.685
adarb1b	trim107	ENSDARP00000113492	ENSDARP00000149545	Adenosine deaminase RNA-specific B1b.	Tripartite motif-containing 107.	0.732
adarb1b	trim109	ENSDARP00000113492	ENSDARP00000084667	Adenosine deaminase RNA-specific B1b.	Tripartite motif-containing 109.	0.732
adarb1b	trim110	ENSDARP00000113492	ENSDARP00000121863	Adenosine deaminase RNA-specific B1b.	Tripartite motif-containing 110.	0.732
adarb1b	trim33l	ENSDARP00000113492	ENSDARP00000106248	Adenosine deaminase RNA-specific B1b.	Tripartite motif-containing 33,-like.	0.732
adarb1b	trim45	ENSDARP00000113492	ENSDARP00000130751	Adenosine deaminase RNA-specific B1b.	Tripartite motif-containing 45.	0.713
ccl35.1	adarb1b	ENSDARP00000132604	ENSDARP00000113492	Chemokine (C-C motif) ligand 35, duplicate 1.	Adenosine deaminase RNA-specific B1b.	0.732
ccl35.1	ccr6b	ENSDARP00000132604	ENSDARP00000128924	Chemokine (C-C motif) ligand 35, duplicate 1.	Chemokine (C-C motif) receptor 6b.	0.677
ccl35.1	cdc40	ENSDARP00000132604	ENSDARP00000060431	Chemokine (C-C motif) ligand 35, duplicate 1.	Cell division cycle 40 homolog (S. cerevisiae).	0.669
ccl35.1	mov10a	ENSDARP00000132604	ENSDARP00000064825	Chemokine (C-C motif) ligand 35, duplicate 1.	Mov10 RISC complex RNA helicase a.	0.670
ccl35.1	mov10b.2	ENSDARP00000132604	ENSDARP00000072953	Chemokine (C-C motif) ligand 35, duplicate 1.	Putative helicase mov-10-B.2; Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).	0.664
ccl35.1	trim107	ENSDARP00000132604	ENSDARP00000149545	Chemokine (C-C motif) ligand 35, duplicate 1.	Tripartite motif-containing 107.	0.732
ccl35.1	trim109	ENSDARP00000132604	ENSDARP00000084667	Chemokine (C-C motif) ligand 35, duplicate 1.	Tripartite motif-containing 109.	0.732
ccl35.1	trim110	ENSDARP00000132604	ENSDARP00000121863	Chemokine (C-C motif) ligand 35, duplicate 1.	Tripartite motif-containing 110.	0.732
ccl35.1	trim33l	ENSDARP00000132604	ENSDARP00000106248	Chemokine (C-C motif) ligand 35, duplicate 1.	Tripartite motif-containing 33,-like.	0.732
ccl35.1	trim45	ENSDARP00000132604	ENSDARP00000130751	Chemokine (C-C motif) ligand 35, duplicate 1.	Tripartite motif-containing 45.	0.713

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.966

expected number of edges:

33

PPI enrichment p-value:

0.24

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

8 of 104

1.18

1.4

2.81e-06

GO:0019538

Protein metabolic process

10 of 228

0.93

1.0

2.09e-06

GO:0044271

Cellular nitrogen compound biosynthetic process

9 of 254

0.84

0.81

2.41e-05

GO:1901566

Organonitrogen compound biosynthetic process

9 of 276

0.8

0.75

4.42e-05

GO:1901564

Organonitrogen compound metabolic process

11 of 473

0.66

0.61

8.82e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 53

1.41

1.88

1.33e-06

GO:0019843

rRNA binding

4 of 41

1.28

0.86

0.0080

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

7 of 55

1.4

1.96

3.12e-07

GO:0044391

Ribosomal subunit

2 of 15

1.42

0.64

0.0470

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:106

Structural constituent of ribosome

7 of 54

1.4

2.01

1.74e-07

CL:103

Structural constituent of ribosome, and Elongation factor

8 of 68

1.36

1.99

5.59e-08

CL:85

Mixed, incl. Translation, and Oxidative phosphorylation

10 of 168

1.07

1.33

5.27e-08

CL:146

Ribosomal protein

3 of 17

1.54

1.13

0.0031

CL:108

Structural constituent of ribosome

4 of 42

1.27

1.05

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

7 of 54

1.4

1.97

3.20e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

7 of 42

1.51

2.28

1.22e-07

GOCC:0044391

Ribosomal subunit

5 of 22

1.65

2.05

9.09e-06

GOCC:0022626

Cytosolic ribosome

4 of 16

1.69

1.85

5.67e-05

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 10

1.77

1.5

0.00070

GOCC:0015934

Large ribosomal subunit

2 of 10

1.59

0.77

0.0277

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 53

1.41

1.96

4.58e-07

KW-0699

rRNA-binding

4 of 39

1.3

1.03

0.0023

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2024

Credits

Access

Info

About