STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alx1ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development ; Belongs to the paired homeobox family. (320 aa)    
Predicted Functional Partners:
ets1
V-ets avian erythroblastosis virus E26 oncogene homolog 1.
    
 
 0.692
zswim6
Zinc finger, SWIM-type-containing 6.
    
 
 0.587
mmd2a
Monocyte to macrophage differentiation-associated 2a.
      
 0.561
tbx15
T-box transcription factor 15.
    
 
 0.558
clec19a
C-type lectin domain-containing 19A.
      
 0.555
ferd3l
Fer3-like bHLH transcription factor.
    
 
 0.517
fam136a
Protein FAM136A; Belongs to the FAM136 family.
      
 0.453
foxd3
Forkhead box D3.
   
 
 0.425
sp8a
Sp8 transcription factor a.
    
 
 0.416
specc1la
Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
      
 0.400
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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