STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serinc5Serine incorporator 5; Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity). Belongs to the TDE1 family. (460 aa)    
Predicted Functional Partners:
tmem106a
Transmembrane protein 106A.
      
 0.744
neu4
Neu4 protein.
    
 
 0.670
samhd1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...]
      
 0.616
tmem106c
Transmembrane protein 106C.
      
 0.587
b4galnt2.2
Beta-1,4-N-acetyl-galactosaminyl transferase 2, tandem duplicate 2.
      
 0.545
pak2a
Non-specific serine/threonine protein kinase.
   
  
 0.484
LOC101887157
Tyrosyl-DNA phosphodiesterase 2a.
   
  
 0.478
gpr17
G_PROTEIN_RECEP_F1_2 domain-containing protein.
      
 0.477
cd4-1
CD4-1 molecule.
      
 0.477
serinc1
Serine incorporator 1.
  
 
 
0.438
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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