node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000152912 | efna1b | ENSDARP00000152912 | ENSDARP00000012577 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin A-L1; Belongs to the ephrin family. | 0.410 |
ENSDARP00000152912 | efna2b | ENSDARP00000152912 | ENSDARP00000101723 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin-A2b; Belongs to the ephrin family. | 0.400 |
ENSDARP00000152912 | efna3b | ENSDARP00000152912 | ENSDARP00000133669 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin-A3b; Belongs to the ephrin family. | 0.472 |
ENSDARP00000152912 | efna5b | ENSDARP00000152912 | ENSDARP00000136933 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin-A5b; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor [...] | 0.400 |
ENSDARP00000152912 | efnb1 | ENSDARP00000152912 | ENSDARP00000024428 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin-B1; Belongs to the ephrin family. | 0.708 |
ENSDARP00000152912 | efnb2a | ENSDARP00000152912 | ENSDARP00000010432 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin-B2a; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morph [...] | 0.410 |
ENSDARP00000152912 | efnb2b | ENSDARP00000152912 | ENSDARP00000079638 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin-B2b; Belongs to the ephrin family. | 0.706 |
ENSDARP00000152912 | efnb3b | ENSDARP00000152912 | ENSDARP00000062002 | Si:dkey-246i14.3; Belongs to the ephrin family. | Efnb3 protein; Belongs to the ephrin family. | 0.706 |
ENSDARP00000152912 | ephb4b | ENSDARP00000152912 | ENSDARP00000088414 | Si:dkey-246i14.3; Belongs to the ephrin family. | Ephrin type-B receptor 4b; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] | 0.609 |
efna1b | ENSDARP00000152912 | ENSDARP00000012577 | ENSDARP00000152912 | Ephrin A-L1; Belongs to the ephrin family. | Si:dkey-246i14.3; Belongs to the ephrin family. | 0.410 |
efna1b | efna2b | ENSDARP00000012577 | ENSDARP00000101723 | Ephrin A-L1; Belongs to the ephrin family. | Ephrin-A2b; Belongs to the ephrin family. | 0.443 |
efna1b | efna3b | ENSDARP00000012577 | ENSDARP00000133669 | Ephrin A-L1; Belongs to the ephrin family. | Ephrin-A3b; Belongs to the ephrin family. | 0.479 |
efna1b | efna5b | ENSDARP00000012577 | ENSDARP00000136933 | Ephrin A-L1; Belongs to the ephrin family. | Ephrin-A5b; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor [...] | 0.518 |
efna1b | efnb1 | ENSDARP00000012577 | ENSDARP00000024428 | Ephrin A-L1; Belongs to the ephrin family. | Ephrin-B1; Belongs to the ephrin family. | 0.676 |
efna1b | efnb2b | ENSDARP00000012577 | ENSDARP00000079638 | Ephrin A-L1; Belongs to the ephrin family. | Ephrin-B2b; Belongs to the ephrin family. | 0.675 |
efna1b | efnb3b | ENSDARP00000012577 | ENSDARP00000062002 | Ephrin A-L1; Belongs to the ephrin family. | Efnb3 protein; Belongs to the ephrin family. | 0.684 |
efna1b | ephb4b | ENSDARP00000012577 | ENSDARP00000088414 | Ephrin A-L1; Belongs to the ephrin family. | Ephrin type-B receptor 4b; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] | 0.621 |
efna2b | ENSDARP00000152912 | ENSDARP00000101723 | ENSDARP00000152912 | Ephrin-A2b; Belongs to the ephrin family. | Si:dkey-246i14.3; Belongs to the ephrin family. | 0.400 |
efna2b | efna1b | ENSDARP00000101723 | ENSDARP00000012577 | Ephrin-A2b; Belongs to the ephrin family. | Ephrin A-L1; Belongs to the ephrin family. | 0.443 |
efna2b | efna3b | ENSDARP00000101723 | ENSDARP00000133669 | Ephrin-A2b; Belongs to the ephrin family. | Ephrin-A3b; Belongs to the ephrin family. | 0.405 |