STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cacybpCalcyclin-binding protein. (227 aa)    
Predicted Functional Partners:
siah1
E3 ubiquitin-protein ligase Siah1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates; Belongs to the SINA (Seven in absentia) family.
    
 0.994
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
   
 0.991
zmynd12
Zinc finger, MYND-type-containing 12.
      
 0.859
siah2l
E3 ubiquitin-protein ligase Siah2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. Induces cellular growth arrest by inhibiting the G2/M transition. May play a role in the regulation of the cellular clock function (By similarity).
    
 
 0.804
erh
Enhancer of rudimentary homolog; May have a role in the cell cycle; Belongs to the E(R) family.
   
  
 0.773
csnk1g1
Casein kinase I isoform gamma-1; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
      
 0.663
scmh1
Scm polycomb group protein homolog 1.
      
 0.644
cyhr1
Cysteine and histidine-rich protein 1.
   
 
 0.622
hspe1
Heat shock 10 protein 1 (Chaperonin 10); Belongs to the GroES chaperonin family.
   
  
 0.606
ssbp3a
Single stranded DNA-binding protein 3a.
      
 0.600
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.