node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000136668 | aph1b | ENSDARP00000136668 | ENSDARP00000011743 | Ncstrn_small domain-containing protein. | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | 0.962 |
ENSDARP00000136668 | aplp1 | ENSDARP00000136668 | ENSDARP00000140309 | Ncstrn_small domain-containing protein. | Amyloid beta (A4) precursor-like protein 1. | 0.640 |
ENSDARP00000136668 | aplp2 | ENSDARP00000136668 | ENSDARP00000071593 | Ncstrn_small domain-containing protein. | Amyloid beta (A4) precursor-like protein 2. | 0.696 |
ENSDARP00000136668 | bace1 | ENSDARP00000136668 | ENSDARP00000131623 | Ncstrn_small domain-containing protein. | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.431 |
ENSDARP00000136668 | notch1a | ENSDARP00000136668 | ENSDARP00000137942 | Ncstrn_small domain-containing protein. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.770 |
ENSDARP00000136668 | notch1b | ENSDARP00000136668 | ENSDARP00000050854 | Ncstrn_small domain-containing protein. | Notch receptor 1b. | 0.770 |
ENSDARP00000136668 | psen1 | ENSDARP00000136668 | ENSDARP00000136264 | Ncstrn_small domain-containing protein. | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. | 0.958 |
ENSDARP00000136668 | psen2 | ENSDARP00000136668 | ENSDARP00000011791 | Ncstrn_small domain-containing protein. | Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. | 0.965 |
ENSDARP00000136668 | psenen | ENSDARP00000136668 | ENSDARP00000090230 | Ncstrn_small domain-containing protein. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. | 0.993 |
ENSDARP00000136668 | zgc:114200 | ENSDARP00000136668 | ENSDARP00000133858 | Ncstrn_small domain-containing protein. | Zgc:114200. | 0.962 |
aph1b | ENSDARP00000136668 | ENSDARP00000011743 | ENSDARP00000136668 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Ncstrn_small domain-containing protein. | 0.962 |
aph1b | aplp1 | ENSDARP00000011743 | ENSDARP00000140309 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Amyloid beta (A4) precursor-like protein 1. | 0.404 |
aph1b | aplp2 | ENSDARP00000011743 | ENSDARP00000071593 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Amyloid beta (A4) precursor-like protein 2. | 0.444 |
aph1b | bace1 | ENSDARP00000011743 | ENSDARP00000131623 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.439 |
aph1b | notch1a | ENSDARP00000011743 | ENSDARP00000137942 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.864 |
aph1b | notch1b | ENSDARP00000011743 | ENSDARP00000050854 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Notch receptor 1b. | 0.780 |
aph1b | psen1 | ENSDARP00000011743 | ENSDARP00000136264 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. | 0.985 |
aph1b | psen2 | ENSDARP00000011743 | ENSDARP00000011791 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. | 0.986 |
aph1b | psenen | ENSDARP00000011743 | ENSDARP00000090230 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. | 0.999 |
aph1b | zgc:114200 | ENSDARP00000011743 | ENSDARP00000133858 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Zgc:114200. | 0.902 |