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cpla2 protein (Danio rerio) - STRING interaction network
"cpla2" - Cytosolic phospholipase A2 in Danio rerio
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cpla2Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (741 aa)    
Predicted Functional Partners:
mapk1
Mitogen-activated protein kinase 1 (369 aa)
       
  0.938
mapk14a
Mitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
       
  0.926
mapk14b
Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
       
  0.925
gna14a
Guanine nucleotide binding protein (G protein), alpha 14a (365 aa)
     
  0.919
gna15.1
Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 (367 aa)
     
  0.914
gna15.2
Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 (367 aa)
     
  0.914
gnaq
Guanine nucleotide binding protein (G protein), q polypeptide (359 aa)
     
  0.914
pla2g4a
Phospholipase A2, group IVA (cytosolic, calcium-dependent) (729 aa)
         
0.900
mapk3
Mitogen-activated protein kinase 3 (392 aa)
       
  0.880
pld1b
Phospholipase D1b (1042 aa)
         
  0.860
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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