| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ccdc47 | emc6 | ENSDARP00000051541 | ENSDARP00000051134 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | ER membrane protein complex subunit 6; Belongs to the EMC6 family. | 0.670 |
| ccdc47 | ncln | ENSDARP00000051541 | ENSDARP00000076240 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.940 |
| ccdc47 | rab5if | ENSDARP00000051541 | ENSDARP00000100542 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | RAB5-interacting factor. | 0.613 |
| ccdc47 | sec61b | ENSDARP00000051541 | ENSDARP00000059012 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.805 |
| ccdc47 | sec61g | ENSDARP00000051541 | ENSDARP00000122360 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | SEC61 translocon gamma subunit. | 0.793 |
| ccdc47 | tmco1 | ENSDARP00000051541 | ENSDARP00000091049 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.984 |
| ccdc47 | tmem147 | ENSDARP00000051541 | ENSDARP00000058382 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Transmembrane protein 147. | 0.929 |
| ccdc47 | zgc:109965 | ENSDARP00000051541 | ENSDARP00000044503 | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | Zgc:109965. | 0.849 |
| emc6 | ccdc47 | ENSDARP00000051134 | ENSDARP00000051541 | ER membrane protein complex subunit 6; Belongs to the EMC6 family. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | 0.670 |
| emc6 | tmco1 | ENSDARP00000051134 | ENSDARP00000091049 | ER membrane protein complex subunit 6; Belongs to the EMC6 family. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.812 |
| farsb | tmco1 | ENSDARP00000007817 | ENSDARP00000091049 | Phenylalanyl-tRNA synthetase subunit beta. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.896 |
| gas7a | tmco1 | ENSDARP00000134671 | ENSDARP00000091049 | Growth arrest-specific 7a. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.836 |
| ncln | ccdc47 | ENSDARP00000076240 | ENSDARP00000051541 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | 0.940 |
| ncln | rab5if | ENSDARP00000076240 | ENSDARP00000100542 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | RAB5-interacting factor. | 0.628 |
| ncln | sec61b | ENSDARP00000076240 | ENSDARP00000059012 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. | 0.764 |
| ncln | sec61g | ENSDARP00000076240 | ENSDARP00000122360 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | SEC61 translocon gamma subunit. | 0.757 |
| ncln | tmco1 | ENSDARP00000076240 | ENSDARP00000091049 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family. | 0.909 |
| ncln | tmem147 | ENSDARP00000076240 | ENSDARP00000058382 | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | Transmembrane protein 147. | 0.985 |
| rab5if | ccdc47 | ENSDARP00000100542 | ENSDARP00000051541 | RAB5-interacting factor. | Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity). | 0.613 |
| rab5if | ncln | ENSDARP00000100542 | ENSDARP00000076240 | RAB5-interacting factor. | Nicalin-1; Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning. Belongs to the nicastrin family. | 0.628 |