STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ercc8Excision repair cross-complementation group 8. (400 aa)    
Predicted Functional Partners:
ercc6
Excision repair cross-complementation group 6.
    
 0.997
ddb1
Damage-specific DNA-binding protein 1.
    
 0.995
uvssa
UV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity); Belongs to the UVSSA family.
   
 
 0.985
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.976
ddb2
DNA damage-binding protein 2; Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV- induced DNA damage. The ubiquitination of histones may facilitate their removal from th [...]
    
 0.962
polr2a
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.932
cul4a
Cullin 4A; Belongs to the cullin family.
    
 0.925
ercc4
Excision repair cross-complementation group 4.
     
 0.913
cul4b
Cullin 4B; Belongs to the cullin family.
    
 0.913
cop1
Novel protein similar to vertebrate ring finger and WD repeat domain 2 (RFWD2, zgc:163067).
    
 
0.902
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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