STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kidins220bKinase D-interacting substrate of 220 kDa B; Downstream target for both neurotrophin and ephrin receptors. May play a role in nerve growth factor (NGF)-induced recruitment of rapgef2 to late endosomes and neurite outgrowth. (1680 aa)    
Predicted Functional Partners:
crk
V-crk sarcoma virus CT10 oncogene homolog (Avian).
    
 0.912
dhx57
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57.
   
 
 0.764
NAV1
Neuron navigator 1.
   
 
 0.745
tmem178
Transmembrane protein 178A; May act as a negative regulator of osteoclast differentiation; Belongs to the TMEM178 family.
   
  
 0.744
lancl2
LanC lantibiotic synthetase component C-like 2 (bacterial).
   
 
 0.733
tenm4
Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May play a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation of oligodendrocytes and myelination of axons. May function as a cellular signal transducer (By similarity). Belongs to the tenascin family. Teneurin subfamily.
    
 
 0.670
chic2
Cysteine-rich hydrophobic domain 2.
      
 0.661
ntrk1
Tyrosine-protein kinase receptor.
    
 0.630
sntg2
Syntrophin, gamma 2.
   
  
 0.620
rnd1b
Rho family GTPase 1 like.
    
 0.613
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (26%) [HD]