STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larp7La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. (555 aa)    
Predicted Functional Partners:
mepce
7SK snRNA methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
   
 
 0.999
hexim1
Protein HEXIM; Probable transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor; Belongs to the HEXIM family.
   
 
 0.997
MEPCE
Si:ch1073-157b13.1.
   
 
 0.997
cdk9
Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.
   
 
 0.985
ccnt1
Cyclin T1; Belongs to the cyclin family.
   
 
 0.932
ccnt2a
Cyclin T2a; Belongs to the cyclin family.
   
 
 0.860
LOC100332095
La ribonucleoprotein 4Aa.
      
 0.842
ccnt2b
Zgc:55690 protein; Belongs to the cyclin family.
   
 
 0.821
mrpl11
Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family.
   
 
 0.801
larp4b
La ribonucleoprotein 4B.
      
 0.750
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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