STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (410 aa)    
Predicted Functional Partners:
skp1
S-phase kinase-associated protein 1A; Belongs to the SKP1 family.
   
 0.999
cul1b
Cullin 1b; Belongs to the cullin family.
    
 0.997
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.996
cul1a
Cullin 1a; Belongs to the cullin family.
    
 0.996
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.988
ccna1
Cyclin A1; Belongs to the cyclin family.
   
 0.978
cks1b
Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
   
 0.975
cdkn1a
Cyclin-dependent kinase inhibitor 1A.
    
 0.974
ccna2
Cyclin A2; Belongs to the cyclin family.
   
 0.965
ccne1
G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily.
   
 0.964
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.