STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
popdc2Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa)    
Predicted Functional Partners:
kcnk2a
Potassium channel, subfamily K, member 2a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.919
kcnk2b
Potassium channel, subfamily K, member 2b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.915
vamp3
Vesicle-associated membrane protein 3 (Cellubrevin).
      
 0.676
xirp1
Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization. Belongs to the Xin family.
   
  
 0.670
mtus2a
Microtubule-associated tumor suppressor candidate 2a.
      
 0.667
hcn4
Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4.
      
 0.665
cav3
Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.
   
  
 0.622
E7EXN1_DANRE
Si:ch211-189k9.2.
      
 0.621
cbr4
Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o- quinones and p-quinones; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.589
kcnk18
Potassium channel, subfamily K, member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.582
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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