node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TMEM216 | ahi1 | ENSDARP00000111752 | ENSDARP00000124018 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Abelson helper integration site 1. | 0.982 |
TMEM216 | arl13b | ENSDARP00000111752 | ENSDARP00000092960 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] | 0.867 |
TMEM216 | cc2d2a | ENSDARP00000111752 | ENSDARP00000150494 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Coiled-coil and C2 domain-containing 2A. | 0.997 |
TMEM216 | cep290 | ENSDARP00000111752 | ENSDARP00000124972 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] | 0.959 |
TMEM216 | pde6d | ENSDARP00000111752 | ENSDARP00000102162 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.675 |
TMEM216 | rpgrip1l | ENSDARP00000111752 | ENSDARP00000107198 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | RPGRIP1-like. | 0.930 |
TMEM216 | tmem67 | ENSDARP00000111752 | ENSDARP00000116688 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | Transmembrane protein 67. | 0.998 |
ahi1 | TMEM216 | ENSDARP00000124018 | ENSDARP00000111752 | Abelson helper integration site 1. | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | 0.982 |
ahi1 | arl13b | ENSDARP00000124018 | ENSDARP00000092960 | Abelson helper integration site 1. | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] | 0.905 |
ahi1 | cc2d2a | ENSDARP00000124018 | ENSDARP00000150494 | Abelson helper integration site 1. | Coiled-coil and C2 domain-containing 2A. | 0.995 |
ahi1 | cep290 | ENSDARP00000124018 | ENSDARP00000124972 | Abelson helper integration site 1. | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] | 0.976 |
ahi1 | ift88 | ENSDARP00000124018 | ENSDARP00000034047 | Abelson helper integration site 1. | Intraflagellar transport 88 homolog. | 0.775 |
ahi1 | inpp5e | ENSDARP00000124018 | ENSDARP00000135950 | Abelson helper integration site 1. | Inositol polyphosphate-5-phosphatase E. | 0.555 |
ahi1 | kif3a | ENSDARP00000124018 | ENSDARP00000107221 | Abelson helper integration site 1. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.735 |
ahi1 | pde6d | ENSDARP00000124018 | ENSDARP00000102162 | Abelson helper integration site 1. | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] | 0.735 |
ahi1 | rpgrip1l | ENSDARP00000124018 | ENSDARP00000107198 | Abelson helper integration site 1. | RPGRIP1-like. | 0.960 |
ahi1 | tmem67 | ENSDARP00000124018 | ENSDARP00000116688 | Abelson helper integration site 1. | Transmembrane protein 67. | 0.993 |
arl13b | TMEM216 | ENSDARP00000092960 | ENSDARP00000111752 | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. | 0.867 |
arl13b | ahi1 | ENSDARP00000092960 | ENSDARP00000124018 | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] | Abelson helper integration site 1. | 0.905 |
arl13b | cc2d2a | ENSDARP00000092960 | ENSDARP00000150494 | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] | Coiled-coil and C2 domain-containing 2A. | 0.897 |