STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
rgs8Regulator of G-protein signaling 8; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptors and dopamine receptors. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to G protein-coupled receptor signaling. (174 aa)    
Predicted Functional Partners:
gnaq
Guanine nucleotide-binding protein (G protein), q polypeptide.
   
 0.767
gna11b
Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class).
    
 0.764
ncdn
Neurochondrin.
      
 0.724
gnai3
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 3.
   
 0.680
gnb3a
Novel protein similar to guanine nucleotide binding protein (G protein) beta polypeptide family.
   
 0.678
gnat2
Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 2.
   
 0.673
gnb2
Guanine nucleotide-binding protein (G protein), beta polypeptide 2.
   
 0.664
gnai2b
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b.
   
 0.659
gnb1b
Guanine nucleotide binding protein (G protein), beta polypeptide 1, like.
   
 0.658
gnb5a
Guanine nucleotide-binding protein subunit beta-5a; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...]
   
 0.658
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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