STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plcd3a1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores (By similarity). (784 aa)    
Predicted Functional Partners:
cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
     
 0.907
ptena
Phosphatase and tensin homolog A; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
    
 0.903
pikfyve
Phosphatidylinositol phosphate 5-kinase type III isoform d.
     
 0.902
mtm1
Myotubularin 1.
     
 0.901
E7F3N0_DANRE
Si:ch211-160o17.2.
     
 0.900
pip5k1ca
Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a.
   
 0.847
dgkza
Diacylglycerol kinase.
   
 0.845
dgkh
Diacylglycerol kinase.
   
 
 0.834
mtmr7b
Myotubularin-related protein 7b.
     
 0.832
ipmkb
Kinase; Belongs to the inositol phosphokinase (IPK) family.
    
 0.831
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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